Antinuclear and Precipitating Auto-antibodies in Sjogren's Syndrome

Precipitating auto-antibodies in the connective tissue diseases.

In a recent communication we described the occurrence in the serum of patients with Sjogren's disease of two factors which reacted to give precipitates with extracts of various tissues. Evidence was provided that both factors were auto-antibodies (Anderson, Gray, Beck, and Kinnear, 1961b). As Sjogren's disease has close associations with the connective tissue diseases (Heaton, 1959; Bunim, 1961...

Hydralazine antinuclear antibodies and the lupus syndrome.

The incidence of patients with positive antinuclear antibody test results rose during three years of treatment with hydralazine. At the end of that period over half of the patients (both rapid and slow acetylators) had titres exceeding 1/20, but the rate of rise was faster in the slow acetylators than in the rapid. There was a significant relation between the cumulative dose of hydralazine and ...

Antinuclear Antibodies

knowledge of gene regulation, particularly in neoplastic cells, this deficit is striking. With our current understanding of chromosomal translocations, point mutations, and gene amplification in tumor cells, it is surprising to read that there is ". . . no difference between cancer and normal DNA . . ." (p. 130). The author spends a fair amount of time discussing possible mechanisms for the car...

Antinuclear antibodies in systemic sclerosis

Antinuclear antibodies in rosacea patients

INTRODUCTION Rosacea is a common inflammatory disorder, characterized by a spectrum of facial manifestations. The clinical similarity to other dermatoses, like lupus erythematosus, might lead to misdiagnosis, particularly in patients with elevated antinuclear antibody titers. AIM To assess the frequency, titer and specificity of antinuclear antibodies in rosacea patients and correlate these f...